Reduced inflammation
Removes plasma containing inflammatory substances and provides treatment. May help reduce overall inflammation and support a healthier body.
Therapeutic Plasma Exchange in Scottsdale
A physician-directed blood filtration treatment delivered through Avinity’s proprietary PlasmaRestore™ Protocol, with guidance from a therapeutic apheresis physician consultant with more than 20 years of clinical experience.
20+
Years of plasma exchange experience
Clinical apheresis, physician-directed
MD
Board-certified nephrologist
Plasmapheresis specialist
Rx
Physician-led medical clinic
Not a med spa, not an IV lounge
Free consultation · No commitment required · Serving Scottsdale, Phoenix & Arizona
This process directly changes what is circulating in your bloodstream
PlasmaRestore™ Protocol
What Is Therapeutic Plasma Exchange (TPE)
Therapeutic Plasma Exchange (TPE) is a medical procedure that filters your blood.
Your blood is circulated through a specialized machine that separates plasma from blood cells. A portion of that plasma containing inflammatory proteins, immune factors, toxins, and circulating debris is removed and replaced with clean fluids (albumin).
At Avinity Health, plasma exchange therapy is delivered through the proprietary PlasmaRestore™ TPE Protocol, which integrates physician oversight, structured treatment delivery, and post-treatment monitoring.
What it addresses
Is Therapeutic Plasma Exchange (TPE) Right for You?
The PlasmaRestore™ protocol is designed by our medical team for individuals who approach their health with intent and seek a more considered, physician-led model of care.
It is suited to those looking for structured, personalised, and medically grounded ways to improve their health.
These are individuals who pay attention to how they feel day to day, and are open to established treatments applied with clinical judgement and evolving insight to support how they function.
Inflammation
Longevity and biological aging
Brain health and memory
Heart and metabolic health
Toxin and waste removal
Immune system regulation
Post-viral recovery
Alzheimer’s disease research
Treatment Applications
By removing and replacing plasma, TPE creates measurable effects across immunity, inflammation, and systemic function. Below are the primary applications Avinity's physician-directed program addresses.
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Inflammation and Immune Regulation
Chronic inflammation drives a wide range of conditions affecting how you feel and function. The PlasmaRestore™ protocol is structured around reducing circulating inflammatory proteins and tracking progress through lab monitoring at each stage of treatment.
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Longevity and Biological Aging
Age-associated proteins and inflammatory factors accumulate in plasma over time and are linked to accelerated biological aging. The PlasmaRestore™ longevity protocol is designed for individuals who want a physician-directed, clinically grounded approach to addressing that burden.
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Brain Health and Cognitive Support
The AMBAR trial demonstrated that plasma exchange may slow cognitive and functional decline in Alzheimer's disease, with separate research examining its potential role in reducing neuroinflammation. At Avinity Health, brain health protocols are evaluated individually and structured around what the current evidence supports.
All PlasmaRestore™ protocols begin with a clinical assessment to determine which application is most appropriate for you and how treatment should be structured based on your current health status and goals.
Support for healthy aging
Research has shown measurable changes in markers linked to biological aging after a series of TPE treatments.
Heart and cholesterol health
Can reduce certain circulating cholesterol particles and lipids linked to cardiovascular risk.
Immune health and regulation
Can remove specific antibodies and immune-related proteins may help stabilize immune response patterns.
Why choose Avinity for TPE
Why Choose Avinity for Therapeutic Plasma Exchange in Scottsdale
Where you undergo plasmapheresis matters.
At Avinity Health, plasma exchange is delivered through the PlasmaRestore™ Protocol, shaped by over 25 years of clinical experience in apheresis-based therapies. This experience informs how each treatment is assessed, performed, and supported.
The protocol is designed around the full treatment journey, from initial evaluation to post-treatment recovery, not just the procedure itself.
Plasma exchange is carried out with the discipline of a hospital-based procedure within a private clinical setting, allowing for a more focused, personalized experience.
For individuals seeking Therapeutic Plasma Exchange in Scottsdale, Phoenix, or Paradise Valley, this approach offers greater clinical clarity, structure, and attention at every stage.
Why choose Avinity for TPE
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Apheresis Physician Consultant
Dr. Leslie F. Thomas, MD
Board-Certified Internal Medicine & Nephrology
A Mayo Clinic-trained nephrologist with more than 20 years of clinical experience in therapeutic plasma exchange and apheresis-based therapies, Dr. Thomas continues to lecture at Mayo Clinic and has dedicated his career to the clinical application of plasma-based treatments. His specialist expertise directly shapes the medical protocols and oversight behind Avinity's PlasmaRestore™ program — bringing a standard of clinical rigor to outpatient plasma exchange that is rarely available outside a major academic medical center.
Therapeutic plasma exchange experience
Nephrology & Internal Medicine
how it works
What to Expect from Therapeutic Plasma Exchange in Scottsdale
Clinical assessment
You begin with a consultation where your medical history, current health, and goals are reviewed.
This step determines whether Therapeutic Plasma Exchange is appropriate before any treatment is scheduled.
Baseline Testing (Know Where You’re Starting)
If you are a candidate, baseline lab work is completed.
This establishes a clear picture of your current health and provides a reference point for your treatment.
Treatment Sessions (The Procedure Itself)
Therapeutic Plasma Exchange using Avinity’s proprietary PlasmaRestore protocol is performed as a series of sessions, typically over several weeks or months.
During each session:
Blood is circulated through a medical device
Plasma is separated and partially replaced
Blood cells are returned to your body
Each session takes approximately 2-4 hours and is completed in a controlled clinical setting.
Post-Treatment Support (Recovery)
After each session, care continues with post-treatment support designed to help your body recover and rebalance.
This may include:
IV support
Hydration and recovery protocols
Clinical monitoring as needed
Ongoing Strategy (If Continued Care Makes Sense)
If appropriate, a maintenance plan is developed based on your results and goals.
Some patients continue with periodic sessions to sustain or build on the effects observed during the initial series.
Is TPE the same as donating plasma?
No. Plasma donation is done to collect plasma for use outside the body. Therapeutic Plasma Exchange is a physician-directed medical treatment where plasma is removed and replaced with clean fluids (albumin) as part of a clinical process. The purpose, setting, and level of medical oversight are entirely different.
Is Therapeutic Plasma Exchange in Scottsdale safe?
When performed under proper medical supervision, Therapeutic Plasma Exchange is a well-established procedure that has been used in hospitals for many decades. At Avinity, treatment is delivered within a structured clinical framework designed to prioritize safety, monitoring, and world-class patient care.
How does Therapeutic Plasma Exchange (TPE) work?
Therapeutic Plasma Exchange works by removing a portion of plasma, the liquid part of your blood that carries proteins, inflammatory substances, and other circulating factors and replacing it with clinically appropriate fluids. This process changes what is circulating in the bloodstream and may influence multiple systems in the body.
For those interested in the underlying science, you can read more about the scientific basis of Therapeutic Plasma Exchange.
How long does a plasma exchange session take?
A typical Therapeutic Plasma Exchange session takes about 2 to 4 hours. The exact duration varies depending on your treatment plan, but sessions are designed to be completed comfortably within a single visit.
How many Therapeutic Plasma Exchange treatments are needed?
The number of treatments can vary based on your health status, goals, and how your body responds. In many cases, treatment is structured as a series of about 3 to 6 sessions, followed by a maintenance phase if appropriate. Some patients report noticing changes after a single session, while others require more treatment to see more long-term effects.
How do I know if I am a candidate for Therapeutic Plasma Exchange?
The best way to determine if Therapeutic Plasma Exchange is appropriate for you is through a consultation. During this visit, your medical history, current health status, and goals are reviewed to determine whether treatment is a good fit.
Is Therapeutic Plasma Exchange FDA-approved?
Therapeutic Plasma Exchange is an FDA-approved medical procedure that has been used in hospital settings for decades for a range of autoimmune and neurological conditions. At Avinity, the Plasma Restore™ protocol applies this established procedure in a structured, physician-directed outpatient setting. Its use for longevity and performance optimization represents an evolving clinical application, and we are transparent about the evidence base during consultation.
What is the difference between therapeutic plasma exchange and plasmapheresis?
The terms are often used interchangeably. Plasmapheresis refers to the process of separating and removing plasma from the blood. Therapeutic Plasma Exchange (TPE) is the clinical application of that process, where the removed plasma is replaced with appropriate fluids as part of a structured treatment protocol. At Avinity Health, TPE is delivered through the PlasmaRestore™ Protocol with guidance from an apheresis physician consultant with more than 20 years of therapeutic plasma exchange experience.
Service Areas
Therapeutic Plasma Exchange Near You in Scottsdale
Avinity Health is located at 11000 N. Scottsdale Road, Suite 100 — accessible from Paradise Valley, Phoenix, Gainey Ranch, and the broader metro area. Patients seeking therapeutic plasma exchange in Arizona come to Avinity Health for the PlasmaRestore™ Protocol: a physician-directed TPE program overseen by a board-certified nephrologist with over 20 years of apheresis experience.
Whether you're searching for TPE near Paradise Valley, therapeutic plasma exchange in Phoenix, or plasmapheresis in Scottsdale, the starting point at Avinity Health is the same: a clinical consultation to confirm candidacy, a structured protocol designed around your physiology, and a care team that remains involved across every session.
our location
11000 N. Scottsdale Road
Suite 100, Scottsdale, AZ
Mon–Fri 9:00 AM – 5:00 PM
Sat 9:00 AM – 12:00 PM
Sun Closed
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480-264-6175